I got my APAS test results yesterday and here's the report:
Well, of the 5 items tested, only 1 was a little over the normal range, my KCT.
I made a chart to compare the results of my APAS tests from 2009-2012. So far, I have done the test 3x already... Looks like there were some improvements in my results over the years... Yipee! :) But the fact remains, I'm still positive for APAS... huhuhu! Hope the next time I test for this, it would be within normal range already... :)
MY
APAS TEST RESULTS
|
|
1st Test*
|
|
2nd Test*
|
|
3rd Test**
|
|
|
7/7/2009
|
|
5/26/2010
|
|
6/26/2012
|
|
|
RESULT
|
CONTROL
|
RESULT
|
CONTROL
|
RESULT
|
NORMAL
RANGE
|
Lupus Anti-coagulants
|
KCT
|
105
|
70
|
90
|
75
|
79
|
52-78
sec
|
APTT
|
30
|
25
|
27
|
25
|
35
|
25-39
sec
|
DRVVT
|
30
|
30
|
35
|
30
|
39
|
37-47
sec
|
Anti-Cardiolipin Antibodies
|
ACA IgG
|
7.52
|
15 U
GPL U/mL
|
4.07
|
15 U
GPL U/mL
|
3.9
|
0-12
GPL U/ml
|
ACA IgM
|
8.58
|
15
MPL U/ml
|
8.13
|
15
MPL U/ml
|
1.2
|
0-10
MPL U/ml
|
*Tested at Reproductive Immunology Center Asia
|
**Tested at Manila Endocrine Laboratory
|
Read on to learn more about APAS test.
Antiphospholipid
Antibody Test (APA)
Antibodies are
special cells that are supposed to help our bodies attack foreign invaders,
like bacteria from colds and infections. Sometimes though, the body mistakes
its own cells for invaders and attacks them, causing a host of problems. This
is the case with antiphospholipid antibodies - they attack our own cells.
Antiphospholipid
antibodies are proteins that circulate around in the bloodstream. These
proteins bind to cell membranes, making them sticky. This prevents our blood
from flowing properly, resulting in blood clots. These antibodies can endanger
the health of both you or your baby. High levels of antiphospholipid antibody
are often associated with unexplained infertility including: recurrent
miscarriage, stillbirth, placental insufficiency, implantation failure and
increased rates of IVF failure.
It is thought that
antiphospholipid antibodies compromise the placenta which nourishes your baby.
Because the antibodies cause clotting, the embryo is cut off from oxygen and
nutrient support. As a result, spontaneous miscarriage or fetal death can occur.
Clotting can also cause distress to the placenta, making it difficult to have a
successful implantation. (Source: sharedjourney.com)
There are several kinds of
antiphospholipid antibodies. The two most commonly measured kinds are 1). lupus
anticoagulant and 2). anticardiolipin antibody. These two are closely related, but are
not the same antibody. This
means that a person can have one and not the other.
1.Lupus Anticoagulant
Lupus anticoagulant is a specific type of
antiphospholipid antibody that exists in your bloodstream. It is actually
a protein, which causes your blood to clot differently in your arteries and
veins than it normally should.
A specialized blood tests
called coagulation tests measure blood clotting and are used to find the lupus
anticoagulant. Here are the tests done:
a). Kaolin Clotting time (KCT)
b). Activated Partial Thromboplastin time
(APPT)
c). Dilute Russel Viper Venom Time (DRVVT)
Each of these tests works to detect lupus
anticoagulant by measuring the time it takes for a sample of your blood to clot
in a test tube. If it takes longer than normal for your blood to clot
inside the test tube, it is more likely that you have lupus anticoagulant in
your blood.
2. Anti-Cardiolipin Antibody (ACA)
Cardiolipin
antibodies are
proteins found in your body that work against cardiolipin. Cardiolipin is a
molecule found in your blood platelets and various cell membranes. It is one of
a group of molecules called phospholipids. You need cardiolipin in order to
help regulate blood clotting throughout your body. Sometimes though, your body
can mistake cardiolipin for an attacking substance. As a result, your body
creates soldier-like molecules to fight against the cardiolipin. (Source: www.sharedjourney.com)
Women with cardiolipin
antibodies have a harder time getting pregnant and carrying their pregnancies
to term. This may be because anti-cardiolipin antibodies can cause tiny blood
clots, preventing blood from flowing to the reproductive organs or placenta.
Treatment
for high antiphospholipid or anticardiolipin antibodies
If you do test high for
antiphospholipid or anticardiolipin antibodies, you may be recommended to take
low-dose aspirin and the anticoagulant Heparin as treatment. Treatment is
aimed at reducing the number of clots in your blood, and restoring blood flow
to the placenta.
If you
are suffering from unexplained infertility or recurrent miscarriages, it might
be a good idea to undergo APAS testing as this might be the cause of your
inability to get pregnant or maintain a pregnancy. Ask your reproductive
endocrinologist or your OB about it.
This
might just help you... Knowledge is power!